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CONTENTS YEAR 1988
1. |
Asian J. Exp.
Sci., Vol. 4, No. 1, 1988; 1-7
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Mechanisms of Platelet
Aggregation and the Anti-aggregatory Effect of Human Plasma
Sheikh A. Saeed and
Anwar-ul-Hassan Gilani
Department of Pharamcology,
The Aga Khan University Medical College,
Karachi, Pakistan. |
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There are many
possible biochemical and physiological pathways of human
platelet aggregation. The three most studied pathways are:
release of ADP; the liberation and metabolism of arachidonic
acid; and the synthesis of platelet activating factor (PAF).
Each of these pathways generates compounds which act as
intracellular mediators to propagate the rapid activation
resulting in platelet aggregation. On the other hand, the
discovery that human blood plasma possesses the ability to
inhibit platelet aggregation has led to the suggestion that
there exists one or more circulating inhibitor(s) of platelet
aggregation named EIPA. The unraveling of EIPA has significant
implications for therapeutic intervention in pathological states
as well as for the understanding of platelet physiology. |
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2. |
Asian J. Exp.
Sci., Vol. 4, No. 1, 1988; 8-13
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Endogenous
Inhibitor of Human Platelet Aggregation: Purification and
Possible Identity
Anwar-ul-Hassan
Gilani and Sheikh A. Saeed
Depatment of Pharmacology,
Faculty of Health Science,
Karachi,
Pakistan
We previously reported that
human plasma inhibits platelet aggregation induced by
arachidonic acid in a concentration-dependent manner and
postulated that human blood may contain one or more inhibitor(s)
of platelet aggregation. We now report that the inhibitor(s) is
proteinaceous in nature because boiling or deproteinization of
plasma with trichloracetic acid abolished inhibitory activity.
The analysis of plasma Cohn fractions revealed that the
inhibitory activity was associated with
a-globulin and
albumin-rich protein fractions of plasma. On specific removal of
albumin from plasma by affinity chromatography, the platelet
aggregation inhibitory activity was reduced by 70%. These
results indicate the presence of endogenous inhibitor(s), one of
which is associated with albumin, in plasma. |
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3. |
Asian J. Exp.
Sci., Vol. 4, No. 1, 1988; 14-20
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A
Univentricular Heart and its Conduction System in AC Triloculare
Biatriatum with a Right Outlet Chamber |
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C. J. van Nie
Department of Anatomy and Embryology,
Medical Faculty, Free University,
Van de Boechorstraat 7, 1081 BT Amsterdam,
The Netherlands.
A
univentricular heart with normal1y related great arteries of a
calf is described. The histological search for the localization
of the conduction system leads to the conclusion that the
described univentricular heart belongs morphogically in fact to
the group of hearts with a hypoplastic right ventricle, while
the atrioventricular node, the common bundle and its branches
are localized normally in the muscular right apical border of
the interventricular defect. Some bizarre coursing cardiac heart
fibres have been observed too. Their genesis and function
remains unknown. |
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4. |
Asian J. Exp.
Sci., Vol. 4, No. 1, 1988; 26-34
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Hormonal/Antihormonal Profile
of Butanolic Extract of Pueraria tuberosa DC |
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R. Mathur Sangeeta Shukla, A. Mathur and
A. O. Prakash
Laboratory of Reproductive Biology,
School of Studies in Zoology,
Jiwaji University, Gwalior - 474011
Investigations on a butanolic
extract of Pueraria tuberosa DC. (tubers) for various
hormonal/antihormonal activities revealed its estrogenic action
when assayed in bilateraily ovariectomized rats. At a higher
dose, administration of the extract together with
diethylstilbestrol, antagonized the latter’s estrogenic effect.
The extract’s estrogenic activity was also demonstrated by its
ability to induce delayed implantation in ovariectomized,
progesterone treated rats. The extract also exhibited a mild
progestational effect. |
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5. |
Asian J. Exp.
Sci., Vol. 4, No. 1, 1988; 27-35
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Histochemical Picture of the
Corpus Allatum Of Supella supellectilium Serville (Blattoidea;
Blatellidae) and some Observations on the Possible Mode of
Origin of The CA - Secretion |
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S. C. Phatak
Department of Biological Sciences,
Rani Durgavati University, Jabalpur - 482001
The secretory cells of the corpus
allatum of S. supellectillium exhibit some variations
with respect to their protein, lipid and RNA contents, during
various stages. In the nymphs, the variation appears to be
related to the process of moulting. All the three particularly
the lipids and RNA are markedly higher in the intermoult period
and are very low during the process of ecdysis. In the adults
also, the protein content is higher in the active stages but is
markedly lesser in the inactive glands. The variation in the
lipid and RNA contents is more pronounced and these are
unusually high in the active glands. The carbohydrate content is
always poor, throughout the life. The relevance of these
observations with regard to the secretion cycle of the gland and
the possible mode of origin of the CA secretion have been
discussed. |
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6. |
Asian J. Exp.
Sci., Vol. 4, No. 1, 1988; 36-44
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Adrenergic and Cholinergic
Receptors in the Isolated Scale Melanophores of a Teleostean
Fish Cirrhinus Mrigala (Ham.) |
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Mohd. Ovasis and Arun K. Gorakh
Department of Biosciences,
Barkatullah University, Bhopal - 462026 (M.P.)
Melanophores
of Cirrhinus mrigala were dispersed in response to
adrenaline, isoprenaline and low doses of dopamine.
Phenylephrine and high doses of dopamine aroused a marked
aggregation in the fish melanophores. Acetylcholine, carbachol,
pilocarpine and nicotine induced a dispersal effect on the
melanophores. Physostigmine per se dispersed the
melanophores. Atropine and scopolamine failed to block the
dispersal effects of cholinergic agonists, while nicotine
blocked the dispersal effect of carbachol. Hexamethonium and
atropine per se aggregated the C. mrigala
melanophores. It is concluded that in Cirrhinus mrigala
melanophores two different types of adrenergic receptors may be
present i.e., alpha aggregatory and beta dispersal in nature.
Results of cholinergic drugs indicate the involvement of
cholinergic nicotinic receptors in the dispersal responses of
melanophores in this fish species. |
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